Biomedical MR Research Group BioMR

Contact information Institute: Radboud University Nijmegen Medical Center, Department of Radiology (767) Address: Geert Grooteplein 10, 6525 GA, Nijmegen, The Netherlands Mail: PO Box 9101, 6500 HB Nijmegen, the Netherlands Phone: +31 24 3614545 (Secretariat) Fax: +31 24 3540866 Internet: www.umcn.nl

Personal information

Name:	Hermien E. Kan
Date of birth:	14-01-1977
Department:	Radiology (667)
Phone number:	+31 24 3619117
Nationality:	Dutch
Email:	H.Kan(at)rad.umcn.nl

Education

2002 – 2006	Ph.D. student at the radiology department of the University Medical Center Nijmegen, The Netherlands.
	Obtained Ph.D. at april 25th 2007
1996 – 2000	MSc at the Faculty of Human Movement Sciences, Free University of Amsterdam, The Netherlands

Honors

2006	FSH Society Sam E. and Mary F. Roberts Nutrition Research Fellowship Grant FSHS-SMRF-003
2004	First prize poster awards in Body and Cardiac Imaging at the Twelfth Scientific Meeting and Exhibition of the ISMRM, Kyoto, Japan
2001	Gerrit Jan van Ingen Schenau scholarship for excellent students

Projects

• Energy metabolism in GAMT deficient knockout mice
• Biomarkers in FSHD

Publications

1. Heerschap A, Kan HE, Nabuurs C, Renema WKJ, Isbrandt D and Heerschap A. In vivo magnetic resonance spectroscopy of transgenic mice with altered expression of guanidinoacetate methyltransferase and creatine kinase isoenzymes In: Creatine kinase in health and disease Subcellular Biochemistry, Vol. 46 Salomons GS. and Wyss M (Eds.) 2007
2. Kan HE, Meeuwissen E, Veltien A, van Asten J, Isbrandt D and Heerschap A. Creatine uptake in brain and skeletal muscle of mice lacking guanidinoacetate methyltransferase assessed by magnetic resonance spectroscopy. J Appl Physiol 102(6):2121-7, 2007
3. Renema WKJ, Kan HE, Wieringa B and Heerschap A. In vivo Magnetic Resonance Spectroscopy of Transgenic Mouse Models with altered high-energy phosphoryl transfer metabolism. NMR Biomed 20(4): 448-467, 2007
4. Kan HE, van der Graaf M, Klomp DWJ, Vlak M, Padberg GW and Heerschap, A. In vivo 13C MR spectroscopy enables simultaneous detection of creatine and phosphocreatine, and determination of creatine turnover in human skeletal muscle. Magn Reson Med 56(5): 953-957, 2006
5. Kan HE, Buse-Pot TE, Peco R, Isbrandt D, Heerschap A and de Haan A. Lower force and impaired performance during high intensity electrical stimulation in skeletal muscle of GAMT deficient knockout mice. Am J Physiol Cell Physiol 289(1): C113-19, 2005
6. Kan HE, Renema WK, Isbrandt D and Heerschap A. Phosphorylated guanidinoacetate partly compensates for the lack of phosphocreatine in skeletal muscle of mice lacking guanidinoacetate methyltransferase. J Physiol 560: 219-229, 2004