Joanes Grandjean

I am currently an assistant professor working 50% the Department of Radiology and Nuclear Medicine and 50% at the Department of Cognitive Neuroscience. I obtained his Master in Neuroscience and PhD in Biomedical Engineering from the ETH Zürich, Switzerland, where I pioneered mouse resting-state functional imaging with magnetic resonance imaging. I joined the Singapore BioImaging Consortium (A*STAR) from 2016 to 2019 as a Senior Research Fellow. I am now part of the BioMR group: Biomedical MR research group, where I use high-field rodent MR imaging techniques and other imaging modalities to study the dynamics of large-scale neuronal networks in animal models of affective and neurodegenerative disorders.  Using functional Magnetic Resonance Imaging (fMRI) as a translational tool applicable to both human and animals, we seek to identify mechanisms leading to the characteristic neuronal networks dysfunction observed with MRI in patient populations with psychiatric and neurological disorders. Selected rodent models replicate behavioral and functional endophenotypes, e.g. for depressive disorders (10.1016/j.neuroimage.2016.08.013) and cerebral amyloidosis (10.1016/j.neuroimage.2016.03.042). These models offer unique opportunities to investigate causal mechanisms leading to large-scale neuronal network signatures where invasive and terminal experiments are precluded in humans. To achieve this, we use genetically-encoded neuromodulatory tools such as optogenetics to reveal the brain-wide functional embedding of neuronal populations of interest across and their response to stress and pharmacological interventions (10.1038/s41467-018-08256-w). We shed light into the mammalian brain functional and structural organization and identify neuronal circuits vulnerable in mental health disorders.