Publications of Arend Heerschap

Accepted or to appear

E. Wiegers, B. Philips, A. Heerschap and M. van der Graaf. "Automatic frequency and phase alignment of in vivo J-difference-edited MR spectra by frequency domain correlation.". Abstract DOI PMID

2018

B. van de Bank, M. Maas, L. Bains, A. Heerschap and T. Scheenen. "Is visual activation associated with changes in cerebral high-energy phosphate levels?", 2018. Abstract DOI PMID
A. Boss, L. Heskamp, V. Breukels, L. Bains, M. van Uden and A. Heerschap. "Oxidative capacity varies along the length of healthy human tibialis anterior.", 2018. Abstract DOI PMID
W. Dou, S. Mastrogiacomo, A. Veltien, H. Alghamdi, X. Walboomers and A. Heerschap. "Visualization of calcium phosphate cement in teeth by zero echo time , javax.xml.bind.JAXBElement@33b97ade, H MRI at high field.", 2018. Abstract DOI PMID
M. Esmaeili, N. Tayari, T. Scheenen, M. Elschot, E. Sandsmark, H. Bertilsson, A. Heerschap, K. Selnæs and T. Bathen. "Simultaneous , javax.xml.bind.JAXBElement@27269985, F-fluciclovine Positron Emission Tomography and Magnetic Resonance Spectroscopic Imaging of Prostate Cancer.", 2018. Abstract DOI PMID
H. Janke, N. Güvener, W. Dou, D. Tiemessen, A. YantiSetiasti, J. Cremers, P. Borm, W. Feitz, A. Heerschap, F. Kiessling and E. Oosterwijk. "Labeling of Collagen Type I Templates with a Naturally Derived Contrast Agent for Noninvasive MR Imaging in Soft Tissue Engineering.", 2018. Abstract DOI PMID
S. Lassche, B. Janssen, T. IJzermans, J. Fütterer, N. Voermans, A. Heerschap, B. Küsters, R. Mann and B. van Engelen. "MRI-Guided Biopsy as a Tool for Diagnosis and Research of Muscle Disorders.", 2018. Abstract DOI PMID
K. Lenting, M. Khurshed, T. Peeters, C. van den Heuvel, S. van Lith, T. de Bitter, W. Hendriks, P. Span, R. Molenaar, D. Botman, K. Verrijp, A. Heerschap, M. Ter Laan, B. Kusters, A. van Ewijk, M. Huynen, C. van Noorden and W. Leenders. "Isocitrate dehydrogenase 1-mutated human gliomas depend on lactate and glutamate to alleviate metabolic stress.", 2018. Abstract DOI PMID
M. Marra, L. Heskamp, K. Mul, S. Lassche, B. van Engelen, A. Heerschap and N. Verdonschot. "Specific muscle strength is reduced in facioscapulohumeral dystrophy: An MRI based musculoskeletal analysis.", 2018. Abstract DOI PMID
A. Rijpma, M. van der Graaf, O. Meulenbroek, M. Olde Rikkert and A. Heerschap. "Altered brain high-energy phosphate metabolism in mild Alzheimer's disease: A 3-dimensional , javax.xml.bind.JAXBElement@5a8b9636, P MR spectroscopic imaging study.", 2018. Abstract DOI PMID
M. Stockebrand, A. Sasani, D. Das, S. Hornig, I. Hermans-Borgmeyer, H. Lake, D. Isbrandt, C. Lygate, A. Heerschap, A. Neu and C. Choe. "A Mouse Model of Creatine Transporter Deficiency Reveals Impaired Motor Function and Muscle Energy Metabolism.", 2018. Abstract DOI PMID
N. Tayari, J. Obels, T. Kobus, T. Scheenen and A. Heerschap. "Simple and broadly applicable automatic quality control for 3D , javax.xml.bind.JAXBElement@38c9074d, H MR spectroscopic imaging data of the prostate.", 2018. Abstract DOI PMID

2017

I. Steinseifer, B. Philips, B. Gagoski, E. Weiland, T. Scheenen and A. Heerschap. "Flexible proton 3D MR spectroscopic imaging of the prostate with low-power adiabatic pulses for volume selection and spiral readout.", 2017. Abstract/PDF DOI PMID
I. Arnoldussen, M. Wiesmann, C. Pelgrim, E. Wielemaker, W. van Duyvenvoorde, P. Amaral-Santos, L. Verschuren, B. Keijser, A. Heerschap, R. Kleemann, P. Wielinga and A. Kiliaan. "Butyrate restores HFD-induced adaptations in brain function and metabolism in mid-adult obese mice.", 2017. Abstract DOI PMID
R. de Haas, D. Das, A. Garanto, H. Renkema, R. Greupink, P. van den Broek, J. Pertijs, R. Collin, P. Willems, J. Beyrath, A. Heerschap, F. Russel and J. Smeitink. "Therapeutic effects of the mitochondrial ROS-redox modulator KH176 in a mammalian model of Leigh Disease.", 2017. Abstract DOI PMID
S. Heskamp, L. Heijmen, D. Gerrits, J. Molkenboer-Kuenen, E. Ter Voert, K. Heinzmann, D. Honess, D. Smith, J. Griffiths, S. Doblas, R. Sinkus, P. Laverman, W. Oyen, A. Heerschap and O. Boerman. "Response Monitoring with [(18)F]FLT PET and Diffusion-Weighted MRI After Cytotoxic 5-FU Treatment in an Experimental Rat Model for Colorectal Liver Metastases.", 2017. Abstract DOI PMID
M. Hoogenboom, D. Eikelenboom, R. van den Bijgaart, A. Heerschap, P. Wesseling, M. den Brok, J. Fütterer and G. Adema. "Impact of MR-guided boiling histotripsy in distinct murine tumor models", 2017.
A. Jager, H. Amiri, N. Bielczyk, S. van Heukelum, A. Heerschap, A. Aschrafi, G. Poelmans, J. Buitelaar, T. Kozicz and J. Glennon. "Cortical control of aggression: GABA signalling in the anterior cingulate cortex.", 2017. Abstract DOI PMID
S. Mastrogiacomo, W. Dou, O. Koshkina, O. Boerman, J. Jansen, A. Heerschap, M. Srinivas and X. Walboomers. "Perfluorocarbon/Gold Loading for Noninvasive in Vivo Assessment of Bone Fillers Using (19)F Magnetic Resonance Imaging and Computed Tomography.", 2017. Abstract DOI PMID
A. Rijpma, M. van der Graaf, M. Lansbergen, O. Meulenbroek, A. Cetinyurek-Yavuz, J. Sijben, A. Heerschap and M. Olde Rikkert. "The medical food Souvenaid affects brain phospholipid metabolism in mild Alzheimer's disease: results from a randomized controlled trial.", 2017. Abstract DOI PMID
N. Tayari, I. Steinseifer, K. Selnæs, T. Bathen, M. Maas and A. Heerschap. "High-Quality 3-Dimensional 1H Magnetic Resonance Spectroscopic Imaging of the Prostate Without Endorectal Receive Coil Using A Semi-LASER Sequence.", 2017. Abstract DOI PMID
E. Wiegers, K. Becker, H. Rooijackers, F. von Samson-Himmelstjerna, C. Tack, A. Heerschap, B. de Galan and M. van der Graaf. "Cerebral blood flow response to hypoglycemia is altered in patients with type 1 diabetes and impaired awareness of hypoglycemia.", 2017. Abstract DOI PMID
M. Wiesmann, V. Zerbi, D. Jansen, D. Lütjohann, A. Veltien, A. Heerschap and A. Kiliaan. "Hypertension, cerebrovascular impairment, and cognitive decline in aged A$beta$PP/PS1 mice", 2017. DOI
M. Wiesmann, B. Zinnhardt, D. Reinhardt, S. Eligehausen, L. Wachsmuth, S. Hermann, P. Dederen, M. Hellwich, M. Kuhlmann, L. Broersen, A. Heerschap, A. Jacobs and A. Kiliaan. "A specific dietary intervention to restore brain structure and function after ischemic stroke.", 2017. Abstract/PDF DOI PMID

2016

E. Ter Voert, L. Heijmen, C. Punt, J. de Wilt, H. van Laarhoven and A. Heerschap. "Reduced respiratory motion artifacts using structural similarity in fast 2D dynamic contrast enhanced MRI of liver lesions.", 2016. Abstract/PDF DOI PMID
M. Wiesmann, M. Roelofs, R. van der Lugt, A. Heerschap, A. Kiliaan and J. Claassen. "Angiotensin II, hypertension, and angiotensin II receptor antagonism: Roles in the behavioural and brain pathology of a mouse model of Alzheimer's disease.", 2016. Abstract DOI PMID
Y. Sun, O. Brauckmann, D. Nixdorf, A. Kentgens, M. Garwood, D. Idiyatullin and A. Heerschap. "Imaging human teeth by phosphorus magnetic resonance with nuclear Overhauser enhancement.", 2016. Abstract DOI PMID
B. Janssen, S. Lassche, M. Hopman, R. Wevers, B. van Engelen and A. Heerschap. "Monitoring creatine and phosphocreatine by (13)C MR spectroscopic imaging during and after (13)C4 creatine loading: a feasibility study.", 2016. Abstract DOI PMID
K. Selnas, R. Vettukattil, H. Bertilsson, A. Wright, A. Heerschap, A. Angelsen, M. Tessem and T. Bathen. "Tissue Microstructure Is Linked to MRI Parameters and Metabolite Levels in Prostate Cancer.", 2016. Abstract DOI PMID
W. Sun, Y. Sun, A. Klar, P. Geutjes, E. Reichmann, A. Heerschap and E. Oosterwijk. "Functional Analysis of Vascularized Collagen/Fibrin Templates by MRI in Vivo.", 2016. Abstract DOI PMID
I. Arnoldussen, V. Zerbi, M. Wiesmann, R. Noordman, S. Bolijn, M. Mutsaers, P. Dederen, R. Kleemann, T. Kooistra, E. van Tol, G. Gross, M. Schoemaker, A. Heerschap, P. Wielinga and A. Kiliaan. "Early intake of long-chain polyunsaturated fatty acids preserves brain structure and function in diet-induced obesity.", 2016. Abstract DOI PMID
M. Hoogenboom, D. Eikelenboom, M. den Brok, A. Veltien, M. Wassink, P. Wesseling, E. Dumont, J. Fütterer, G. Adema and A. Heerschap. "In vivo MR guided boiling histotripsy in a mouse tumor model evaluated by MRI and histopathology.", 2016. Abstract DOI PMID
B. Janssen, N. Voet, A. Geurts, B. van Engelen and A. Heerschap. "Quantitative MRI reveals decelerated fatty infiltration in muscles of active FSHD patients.", 2016. Abstract DOI PMID
T. Laudadio, A. Croitor Sava, D. Sima, A. Wright, A. Heerschap, N. Mastronardi and S. Van Huffel. "Hierarchical non-negative matrix factorization applied to three-dimensional 3hspace0.167emT MRSI data for automatic tissue characterization of the prostate.", 2016. Abstract DOI PMID
M. Wiesmann, V. Zerbi, D. Jansen, R. Haast, D. Lütjohann, L. Broersen, A. Heerschap and A. Kiliaan. "A Dietary Treatment Improves Cerebral Blood Flow and Brain Connectivity in Aging apoE4 Mice.", 2016. Abstract DOI PMID
E. Wiegers, H. Rooijackers, C. Tack, A. Heerschap, B. de Galan and M. van der Graaf. "Brain lactate concentration falls in response to hypoglycemia in patients with type 1 diabetes and impaired awareness of hypoglycemia.", 2016. Abstract/PDF DOI PMID

2015

M. Haberl, V. Zerbi, A. Veltien, M. Ginger, A. Heerschap and A. Frick. "Structural-functional connectivity deficits of neocortical circuits in the Fmr1-/y mouse model of autism", 2015.
M. Hoogenboom, D. Eikelenboom, M. den Brok, A. Heerschap, J. Fütterer and G. Adema. "Mechanical high-intensity focused ultrasound destruction of soft tissue: working mechanisms and physiologic effects.", 2015. Abstract DOI PMID
M. Haberl, V. Zerbi, A. Veltien, M. Ginger, A. Heerschap and A. Frick. "Structural-functional connectivity deficits of neocortical circuits in the Fmr1 (-/y) mouse model of autism.", 2015. Abstract DOI PMID
S. Alex, A. Boss, A. Heerschap and S. Kersten. "Exercise training improves liver steatosis in mice.", 2015. Abstract DOI PMID
M. Coelho, P. Nunes, V. Mendes, B. Manadas, A. Heerschap and J. Jones. "Effect of Global ATGL Knockout on Murine Fasting Glucose Kinetics.", 2015. Abstract DOI PMID
M. Hoogenboom, D. Eikelenboom, M. den Brok, A. Heerschap, J. Fütterer and G. Adema. "Mechanical high-intensity focused ultrasound destruction of soft tissue: working mechanisms and physiologic effects.", 2015. Abstract DOI PMID
M. Hoogenboom, M. van Amerongen, D. Eikelenboom, M. Wassink, M. den Brok, C. Hulsbergen-van de Kaa, E. Dumont, G. Adema, A. Heerschap and J. Fütterer. "Development of a high-field MR-guided HIFU setup for thermal and mechanical ablation methods in small animals.", 2015. Abstract DOI PMID
T. Kobus, J. van der Laak, M. Maas, T. Hambrock, C. Bruggink, C. Hulsbergen-van de Kaa, T. Scheenen and A. Heerschap. "Contribution of Histopathologic Tissue Composition to Quantitative MR Spectroscopy and Diffusion-weighted Imaging of the Prostate.", 2015. Abstract DOI PMID
M. Srinivas, J. Tel, G. Schreibelt, F. Bonetto, L. Cruz, H. Amiri, A. Heerschap, C. Figdor and I. de Vries. "PLGA-encapsulated perfluorocarbon nanoparticles for simultaneous visualization of distinct cell populations by 19F MRI.", 2015. Abstract DOI PMID
P. van Ewijk, S. Paglialunga, M. Kooi, P. Nunes, A. Gemmink, J. Slenter, E. Kornips, J. Jörgensen, J. Hoeks, J. Wildberger, M. Hesselink, J. Glatz, A. Heerschap, S. Kersten, P. Schrauwen and V. Schrauwen-Hinderling. "Effects of high-fat feeding on ectopic fat storage and postprandial lipid metabolism in mouse offspring.", 2015. Abstract DOI PMID
M. Wiesmann, C. Capone, V. Zerbi, L. Mellendijk, A. Heerschap, J. Claassen and A. Kiliaan. "Hypertension Impairs Cerebral Blood Flow in a Mouse Model for Alzheimer's Disease.", 2015. Abstract PMID
M. Wiesmann, V. Zerbi, M. Roelofs, R. Der Van Lugt, A. Heerschap, J. Claassen and A. Kiliaan. "Effect of angii-induced hypertension and antihypertensive treatment on pathological changes in a mouse model for alzheimer's disease", 2015. Abstract/PDF DOI PMID
C. Janssen, V. Zerbi, M. Mutsaers, M. Jochems, C. Vos, J. Vos, B. Berg, E. van Tol, G. Gross, Z. Jouni, A. Heerschap and A. Kiliaan. "Effect of perinatally supplemented flavonoids on brain structure, circulation, cognition, and metabolism in C57BL/6J mice", 2015. Abstract/PDF DOI PMID
J. van Asten, R. Vettukattil, T. Buckle, S. Rottenberg, F. van Leeuwen, T. Bathen and A. Heerschap. "Increased levels of choline metabolites are an early marker of docetaxel treatment response in BRCA1-mutated mouse mammary tumors: an assessment by ex vivo proton magnetic resonance spectroscopy", 2015. Abstract/PDF DOI PMID
L. Heijmen, E. Ter Voert, W. Oyen, C. Punt, D. van Spronsen, A. Heerschap, L. de Geus-Oei and H. van Laarhoven. "Multimodality imaging to predict response to systemic treatment in patients with advanced colorectal cancer", 2015. Abstract/PDF DOI PMID
J. Winfield, M. Papoutsaki, H. Ragheb, D. Morris, A. Heerschap, E. Ter Voert, J. Kuijer, I. Pieters, N. Douglas, M. Orton, N. Desouza and Q. Consortium. "Development of a diffusion-weighted MRI protocol for multi-centre abdominal imaging and evaluation of the effects of fasting on measurement of apparent diffusion coefficients (ADCs) in healthy liver", 2015. Abstract/PDF PMID
C. Janssen, V. Zerbi, M. Mutsaers, B. de Jong, M. Wiesmann, I. Arnoldussen, B. Geenen, A. Heerschap, F. Muskiet, Z. Jouni, E. van Tol, G. Gross, J. Homberg, B. Berg and A. Kiliaan. "Impact of dietary n-3 polyunsaturated fatty acids on cognition, motor skills and hippocampal neurogenesis in developing C57BL/6J mice", 2015. Abstract/PDF DOI PMID
H. Amiri, M. Srinivas, A. Veltien, M. van Uden, I. de Vries and A. Heerschap. "Cell tracking using (19)F magnetic resonance imaging: Technical aspects and challenges towards clinical applications", 2015. Abstract/PDF DOI PMID
I. Steinseifer, J. van Asten, E. Weiland, T. Scheenen, M. Maas and A. Heerschap. "Improved volume selective (1) H MR spectroscopic imaging of the prostate with gradient offset independent adiabaticity pulses at 3 tesla", 2015. Abstract/PDF DOI PMID
M. Lagemaat, M. Maas, E. Vos, A. Bitz, S. Orzada, E. Weiland, M. van Uden, T. Kobus, A. Heerschap and T. Scheenen. "(31) P MR spectroscopic imaging of the human prostate at 7 T: T1 relaxation times, Nuclear Overhauser Effect, and spectral characterization", 2015. Abstract/PDF DOI PMID
M. Esmaeili, S. Moestue, B. Hamans, A. Veltien, A. Kristian, O. Engebraaten, G. Maelandsmo, I. Gribbestad, T. Bathen and A. Heerschap. "In Vivo (31) P magnetic resonance spectroscopic imaging (MRSI) for metabolic profiling of human breast cancer xenografts", 2015. Abstract/PDF DOI PMID
T. Kobus, A. Wright, E. Weiland, A. Heerschap and T. Scheenen. "Metabolite ratios in (1) H MR spectroscopic imaging of the prostate", 2015. Abstract/PDF DOI PMID

2014

D. de Groot, L. Linders, R. Kayser, R. Nederlof, V. de Groot, M. Bogaart, F. Kuper, A. Wolterbeek, M. Radonjic, E. de Vries, A. Veltien and A. Heerschap. "Perinatal exposure to DOTC (di-n-octyltin dichloride) affects brain development. A study in rats using MRI (magnetic resonance imaging), [18F]FDG brain PET and genome wide gene expression profiling", 2014.
V. Zerbi, M. Wiesmann, T. Emmerzaal, D. Jansen, M. Van Beek, M. Mutsaers, C. Beckmann, A. Heerschap and A. Kiliaan. "Resting-State Functional Connectivity Changes in Aging apoE4 and apoE-KO Mice", 2014. Abstract/PDF DOI PMID
B. Janssen, S. Pillen, N. Voet, A. Heerschap, B. van Engelen and N. van Alfen. "Quantitative muscle ultrasound versus quantitative MRI in facioscapulohumeral dystrophy", 2014. Abstract/PDF DOI PMID
L. Heijmen, E. Ter Voert, C. Punt, A. Heerschap, W. Oyen, J. Bussink, C. Sweep, P. Laverman, P. Span, L. de Geus-Oei, O. Boerman and H. van Laarhoven. "Monitoring hypoxia and vasculature during bevacizumab treatment in a murine colorectal cancer model", 2014. Abstract DOI PMID
M. Ventura, O. Boerman, C. de Korte, M. Rijpkema, A. Heerschap, E. Oosterwijk, J. Jansen and X. Walboomers. "Preclinical Imaging in Bone Tissue Engineering", 2014. Abstract/PDF DOI PMID
Y. Zhang, Y. Sun, X. Yang, J. Hilborn, A. Heerschap and D. Ossipov. "Injectable In Situ Forming Hybrid Iron Oxide-Hyaluronic Acid Hydrogel for Magnetic Resonance Imaging and Drug Delivery", 2014. Abstract/PDF DOI PMID
Y. Sun, P. Geutjes, E. Oosterwijk and A. Heerschap. "In vivo MR imaging of type I collagen scaffold in rat: improving visualization of bladder and subcutaneous implants", 2014. Abstract/PDF DOI PMID
P. Nunes, A. Wright, A. Veltien, J. van Asten, C. Tack, J. Jones and A. Heerschap. "Dietary lipids do not contribute to the higher hepatic triglyceride levels of fructose- compared to glucose-fed mice", 2014. Abstract/PDF DOI PMID
B. Janssen, N. Voet, C. Nabuurs, H. Kan, J. de Rooy, A. Geurts, G. Padberg, B. van Engelen and A. Heerschap. "Distinct Disease Phases in Muscles of Facioscapulohumeral Dystrophy Patients Identified by MR Detected Fat Infiltration", 2014. Abstract/PDF DOI PMID
M. Lagemaat, E. Vos, M. Maas, A. Bitz, S. Orzada, M. van Uden, T. Kobus, A. Heerschap and T. Scheenen. "Phosphorus Magnetic Resonance Spectroscopic Imaging at 7 T in Patients With Prostate Cancer", 2014. Abstract DOI PMID
M. Ventura, Y. Sun, S. Cremers, P. Borm, Z. Birgani, P. Habibovic, A. Heerschap, P. van der Kraan, J. Jansen and X. Walboomers. "A theranostic agent to enhance osteogenic and magnetic resonance imaging properties of calcium phosphate cements", 2014. Abstract/PDF DOI PMID
V. Zerbi, D. Jansen, M. Wiesmann, X. Fang, L. Broersen, A. Veltien, A. Heerschap and A. Kiliaan. "Multinutrient diets improve cerebral perfusion and neuroprotection in a murine model of Alzheimer's disease", 2014. Abstract/PDF DOI PMID
D. Jansen, V. Zerbi, C. Janssen, D. van Rooij, B. Zinnhardt, P. Dederen, A. Wright, L. Broersen, D. Lütjohann, A. Heerschap and A. Kiliaan. "Impact of a multi-nutrient diet on cognition, brain metabolism, hemodynamics, and plasticity in apoE4 carrier and apoE knockout mice", 2014. Abstract/PDF DOI PMID
P. Nunes, I. Jarak, A. Heerschap and J. Jones. "Resolving futile glucose cycling and glycogenolytic contributions to plasma glucose levels following a glucose load", 2014. Abstract/PDF DOI PMID
T. Kobus, A. Wright, J. Van Asten, A. Heerschap and T. Scheenen. "In vivo 1 H MR spectroscopic imaging of aggressive prostate cancer: Can we detect lactate?", 2014. Abstract/PDF DOI PMID

2013

B. Hamans, A. Navis, A. Wright, P. Wesseling, A. Heerschap and W. Leenders. "Multivoxel 1H MR spectroscopy is superior to contrast-enhanced MRI for response assessment after anti-angiogenic treatment of orthotopic human glioma xenografts and provides handles for metabolic targeting", 2013. Abstract/PDF DOI PMID
E. Aarntzen, M. Srinivas, G. Schreibelt, A. Heerschap, C. Punt, C. Figdor, W. Oyen and I. de Vries. "Reducing cell number improves the homing of dendritic cells to lymph nodes upon intradermal vaccination", 2013. Abstract/PDF DOI PMID
D. Jansen, V. Zerbi, I. Arnoldussen, M. Wiesmann, A. Rijpma, X. Fang, P. Dederen, M. Mutsaers, L. Broersen, D. Lütjohann, M. Miller, L. Joosten, A. Heerschap and A. Kiliaan. "Effects of Specific Multi-Nutrient Enriched Diets on Cerebral Metabolism, Cognition and Neuropathology in AÃŽÂ²PPswe-PS1dE9 Mice", 2013. Abstract DOI PMID
H. Prinsen, A. Heerschap, G. Bleijenberg, M. Zwarts, J. Leer, J. van Asten, M. van der Graaf, M. Rijpkema and H. van Laarhoven. "Magnetic resonance spectroscopic imaging and volumetric measurements of the brain in patients with postcancer fatigue: a randomized controlled trial", 2013. Abstract/PDF DOI PMID
F. Arias-Mendoza, G. Payne, K. Zakian, M. Stubbs, O. O'Connor, H. Mojahed, M. Smith, A. Schwarz, A. Shukla-Dave, F. Howe, H. Poptani, S. Lee, R. Pettengel, S. Schuster, D. Cunningham, A. Heerschap, J. Glickson, J. Griffiths, J. Koutcher, M. Leach and T. Brown. "Noninvasive Phosphorus Magnetic Resonance Spectroscopic Imaging Predicts Outcome to First-line Chemotherapy in Newly Diagnosed Patients with Diffuse Large B-Cell Lymphoma", 2013. Abstract DOI PMID
C. Choe, D. Atzler, P. Wild, A. Carter, R. Böger, F. Ojeda, O. Simova, M. Stockebrand, K. Lackner, C. Nabuurs, B. Marescau, T. Streichert, C. Müller, N. Lüneburg, P. De Deyn, R. Benndorf, S. Baldus, C. Gerloff, S. Blankenberg, A. Heerschap, P. Grant, T. Magnus, T. Zeller, D. Isbrandt and E. Schwedhelm. "Homoarginine Levels are Regulated by L-Arginine:Glycine Amidinotransferase and Affect Stroke Outcome: Results from Human and Murine Studies", 2013. Abstract/PDF DOI PMID
L. Heijmen, C. Punt, E. Ter Voert, L. de Geus-Oei, A. Heerschap, J. Bussink, C. Sweep, V. Zerbi, W. Oyen, P. Span, O. Boerman and H. van Laarhoven. "Monitoring the effects of bevacizumab beyond progression in a murine colorectal cancer model: a functional imaging approach", 2013. Abstract/PDF DOI PMID
H. Prinsen, M. Hopman, M. Zwarts, J. Leer, A. Heerschap, G. Bleijenberg and H. van Laarhoven. "Maximal exercise performance in patients with postcancer fatigue", 2013. Abstract/PDF DOI PMID
D. Jansen, V. Zerbi, C. Janssen, P. Dederen, M. Mutsaers, A. Hafkemeijer, A. Janssen, C. Nobelen, A. Veltien, J. Asten, A. Heerschap and A. Kiliaan. "A Longitudinal Study of Cognition, Proton MR Spectroscopy and Synaptic and Neuronal Pathology in Aging Wild-type and AÃŽÂ²PPswe-PS1dE9 Mice", 2013. Abstract/PDF DOI PMID
H. Prinsen, G. Bleijenberg, L. Heijmen, M. Zwarts, J. Leer, A. Heerschap, M. Hopman and H. van Laarhoven. "The role of physical activity and physical fitness in postcancer fatigue: a randomized controlled trial", 2013. Abstract/PDF DOI PMID
A. Navis, A. Bourgonje, P. Wesseling, A. Wright, W. Hendriks, K. Verrijp, J. van der Laak, A. Heerschap and W. Leenders. "Effects of Dual Targeting of Tumor Cells and Stroma in Human Glioblastoma Xenografts with a Tyrosine Kinase Inhibitor against c-MET and VEGFR2", 2013. Abstract DOI PMID
E. Aarntzen, M. Srinivas, F. Bonetto, L. Cruz, P. Verdijk, G. Schreibelt, M. van de Rakt, W. Lesterhuis, M. Van Riel, C. Punt, G. Adema, A. Heerschap, C. Figdor, W. Oyen and I. de Vries. "Targeting of 111In-labeled dendritic cell human vaccines improved by reducing number of cells", 2013. Abstract/PDF DOI PMID
K. van de Ven, C. Tack, A. Heerschap, M. van der Graaf and B. de Galan. "Patients with type 1 diabetes exhibit altered cerebral metabolism during hypoglycemia", 2013. Abstract/PDF DOI PMID
K. Selnaes, I. Gribbestad, H. Bertilsson, A. Wright, A. Angelsen, A. Heerschap and M. Tessem. "Spatially matched in vivo and ex vivo MR metabolic profiles of prostate cancer - investigation of a correlation with Gleason score", 2013. Abstract/PDF DOI PMID
V. Zerbi, M. Kleinnijenhuis, X. Fang, D. Jansen, A. Veltien, J. Van Asten, N. Timmer, P. Dederen, A. Kiliaan and A. Heerschap. "Gray and white matter degeneration revealed by diffusion in an Alzheimer mouse model", 2013. Abstract/PDF DOI PMID
M. Ventura, Y. Sun, V. Rusu, P. Laverman, P. Borm, A. Heerschap, E. Oosterwijk, O. Boerman, J. Jansen and X. Walboomers. "Dual Contrast Agent for Computed Tomography and Magnetic Resonance Hard Tissue Imaging", 2013. Abstract/PDF DOI PMID
E. Ter Voert, L. Heijmen, J. de Wilt, J. Bussink, C. Punt, H. van Laarhoven and A. Heerschap. "Reproducibility and biological basis of in vivo T(2) * magnetic resonance imaging of liver metastasis of colorectal cancer", 2013. Abstract/PDF DOI PMID
C. Nabuurs, C. Choe, A. Veltien, H. Kan, L. Van Loon, R. Rodenburg, J. Matschke, B. Wieringa, G. Kemp, D. Isbrandt and A. Heerschap. "Disturbed energy metabolism and muscular dystrophy caused by pure creatine deficiency are reversible by creatine intake", 2013. Abstract DOI PMID
C. Choe, C. Nabuurs, M. Stockebrand, A. Neu, P. Nunes, F. Morellini, K. Sauter, S. Schillemeit, I. Hermans-Borgmeyer, B. Marescau, A. Heerschap and D. Isbrandt. "L-arginine:glycine amidinotransferase deficiency protects from metabolic syndrome", 2013. Abstract/PDF DOI PMID
L. Heijmen, E. Ter Voert, I. Nagtegaal, P. Span, J. Bussink, C. Punt, J. de Wilt, F. Sweep, A. Heerschap and H. van Laarhoven. "Diffusion-weighted MR imaging in liver metastases of colorectal cancer: reproducibility and biological validation", 2013. Abstract/PDF DOI PMID
I. Steinseifer, J. Wijnen, B. Hamans, A. Heerschap and T. Scheenen. "Metabolic imaging of multiple X-nucleus resonances", 2013. Abstract/PDF DOI PMID
V. Zerbi, D. Jansen, P. Dederen, A. Veltien, B. Hamans, Y. Liu, A. Heerschap and A. Kiliaan. "Microvascular cerebral blood volume changes in aging APP(swe)/PS1 (dE9) AD mouse model: a voxel-wise approach", 2013. Abstract/PDF DOI PMID
A. Wright, T. Kobus, K. Selnaes, I. Gribbestad, E. Weiland, T. Scheenen and A. Heerschap. "Quality control of prostate (1) ?H MRSI data", 2013. Abstract/PDF DOI PMID

2012

E. Aarntzen, M. Srinivas, P. Walczak, M. Janowski, A. Heerschap, I. de Vries, C. Figdor, J. Bulte and W. Oyen. "In Vivo Tracking Techniques for Cellular Regeneration, Replacement, and Redirection", 2012. Abstract/PDF DOI PMID
F. Bonetto, M. Srinivas, B. Weigelin, L. Cruz, A. Heerschap, P. Friedl, C. Figdor and I. de Vries. "A large-scale (19)F MRI-based cell migration assay to optimize cell therapy", 2012. Abstract/PDF DOI PMID
L. Heijmen, M. Verstappen, E. Ter Voert, C. Punt, W. Oyen, L. de Geus-Oei, J. Hermans, A. Heerschap and H. van Laarhoven. "Tumour response prediction by diffusion-weighted MR imaging: ready for clinical use?", 2012. Abstract/PDF DOI PMID
A. Idema, A. Hoffmann, H. Boogaarts, E. Troost, P. Wesseling, A. Heerschap, W. van der Graaf, J. Grotenhuis and W. Oyen. "3'-Deoxy-3'-18F-Fluorothymidine PET-Derived Proliferative Volume Predicts Overall Survival in High-Grade Glioma Patients", 2012. Abstract/PDF DOI PMID
K. SelnÃƒÂ¦s, A. Heerschap, L. Jensen, M. Tessem, G. Schweder, P. Goa, T. Viset, A. Angelsen and I. Gribbestad. "Peripheral Zone Prostate Cancer Localization by Multiparametric Magnetic Resonance at 3 T: Unbiased Cancer Identification by Matching to Histopathology", 2012. Abstract DOI PMID
K. van de Ven, M. van der Graaf, C. Tack, A. Heerschap and B. de Galan. "Steady-state brain glucose concentrations during hypoglycemia in healthy humans and patients with type 1 diabetes", 2012. Abstract/PDF DOI PMID
P. Nunes, T. van de Weijer, A. Veltien, H. Arnts, M. Hesselink, J. Glatz, P. Schrauwen, C. Tack and A. Heerschap. "Increased intramyocellular lipids but unaltered in vivo mitochondrial oxidative phosphorylation in skeletal muscle of adipose triglyceride lipase-deficient mice", 2012. Abstract/PDF DOI PMID
J. Wijnen, A. Idema, M. Stawicki, M. Lagemaat, P. Wesseling, A. Wright, T. Scheenen and A. Heerschap. "Quantitative short echo time (1) H MRSI of the peripheral edematous region of human brain tumors in the differentiation between glioblastoma, metastasis, and meningioma", 2012. Abstract/PDF DOI PMID
H. Prinsen, G. Bleijenberg, M. Zwarts, M. Hopman, A. Heerschap and H. van Laarhoven. "Physiological and neurophysiological determinants of postcancer fatigue: design of a randomized controlled trial", 2012. Abstract/PDF DOI PMID
C. Nabuurs, C. Hilbers, B. Wieringa and A. Heerschap. "Interpretation of 31P NMR saturation transfer experiments: do not forget the spin relaxation properties", 2012. Abstract/PDF DOI PMID
T. Kobus, A. Bitz, M. van Uden, M. Lagemaat, E. Rothgang, S. Orzada, A. Heerschap and T. Scheenen. "In Vivo (31) P MR spectroscopic imaging of the human prostate at 7 T: Safety and feasibility", 2012. Abstract/PDF DOI PMID
A. Wright and A. Heerschap. "Simple baseline correction for (1) H MRSI data of the prostate", 2012. Abstract/PDF DOI PMID
I. Desar, E. Ter Voert, T. Hambrock, J. van Asten, D. van Spronsen, P. Mulders, A. Heerschap, W. van der Graaf, H. van Laarhoven and C. van Herpen. "Functional MRI techniques demonstrate early vascular changes in renal cell cancer patients treated with sunitinib: a pilot study", 2012. Abstract/PDF DOI PMID
M. Lagemaat, C. Zechmann, J. Fütterer, E. Weiland, J. Lu, G. Villeirs, B. Holshouser, P. van Hecke, M. Lemort, H. Schlemmer, J. Barentsz, S. Roell, A. Heerschap and T. Scheenen. "Reproducibility of 3D (1)H MR spectroscopic imaging of the prostate at 1.5T", 2012. Abstract/PDF DOI PMID
A. Wright, L. Buydens and A. Heerschap. "A phase and frequency alignment protocol for (1)H MRSI data of the prostate", 2012. Abstract/PDF DOI PMID

2011

E. Ter Voert, L. Heijmen, H. van Laarhoven and A. Heerschap. "In vivo magnetic resonance spectroscopy of liver tumors and metastases", 2011. Abstract/PDF DOI PMID
F. Bonetto, M. Srinivas, A. Heerschap, R. Mailliard, E. Ahrens, C. Figdor and I. de Vries. "A novel (19)F agent for detection and quantification of human dendritic cells using magnetic resonance imaging", 2011. Abstract/PDF DOI PMID
I. Desar, C. van Herpen, J. van Asten, W. Fiedler, S. Marreaud, J. Timmer-Bonte, E. Ter Voert, A. Lambiase, C. Bordignon, A. Heerschap and H. van Laarhoven. "Factors affecting the unexpected failure of DCE-MRI to determine the optimal biological dose of the vascular targeting agent NGR-hTNF in solid cancer patients", 2011. Abstract/PDF DOI PMID
M. van der Graaf, J. de Haan, P. Smits, A. Mulder, A. Heerschap and C. Tack. "The effect of acute exercise on glycogen synthesis rate in obese subjects studied by 13C MRS", 2011. Abstract/PDF DOI PMID
A. Navis, B. Hamans, A. Claes, A. Heerschap, J. Jeuken, P. Wesseling and W. Leenders. "Effects of targeting the VEGF and PDGF pathways in diffuse orthotopic glioma models", 2011. Abstract/PDF DOI PMID
G. Postma, J. Luts, A. Idema, M. Julia-Sapé, A. Moreno-Torres, W. Gajewicz, J. Suykens, A. Heerschap, S. Huffel and L. Buydens. "On the relevance of automatically selected single-voxel MRS and multimodal MRI and MRSI features for brain tumour differentiation", 2011. Abstract/PDF DOI PMID
A. Sava, D. Sima, J. Poullet, A. Wright, A. Heerschap and S. Huffel. "Exploiting spatial information to estimate metabolite levels in two-dimensional MRSI of heterogeneous brain lesions", 2011. Abstract/PDF DOI PMID
T. Scheenen, J. Fütterer, E. Weiland, P. van Hecke, M. Lemort, C. Zechmann, H. Schlemmer, D. Broome, G. Villeirs, J. Lu, J. Barentsz, S. Roell and A. Heerschap. "Discriminating cancer from noncancer tissue in the prostate by 3-dimensional proton magnetic resonance spectroscopic imaging: a prospective multicenter validation study", 2011. Abstract/PDF PMID
L. Blanchet, P. Krooshof, G. Postma, A. Idema, B. Goraj, A. Heerschap and L. Buydens. "Discrimination between metastasis and glioblastoma multiforme based on morphometric analysis of MR images", 2011. Abstract/PDF DOI PMID
E. Fuster-Garcia, C. Navarro, J. Vicente, S. Tortajada, J. García-Gómez, C. Sáez, J. Calvar, J. Griffiths, M. Julia-Sapé, F. Howe, J. Pujol, A. Peet, A. Heerschap, A. Moreno-Torres, M. Martínez-Bisbal, B. Martínez-Granados, P. Wesseling, W. Semmler, J. Capellades, C. Majós, A. Alberich-Bayarri, A. Capdevila, D. Monleón, L. Martí-Bonmatí, C. Arús, B. Celda and M. Robles. "Compatibility between 3T 1H SV-MRS data and automatic brain tumour diagnosis support systems based on databases of 1.5T 1H SV-MRS spectra", 2011. Abstract/PDF DOI PMID
B. Hamans, A. Andreychenko, A. Heerschap, S. Wijmenga and M. Tessari. "NMR at earth's magnetic field using para-hydrogen induced polarization", 2011. Abstract/PDF DOI PMID
T. Kobus, T. Hambrock, C. de Hulsbergen-van Kaa, A. Wright, J. Barentsz, A. Heerschap and T. Scheenen. "In Vivo Assessment of Prostate Cancer Aggressiveness Using Magnetic Resonance Spectroscopic Imaging at 3 T with an Endorectal Coil", 2011. Abstract/PDF DOI PMID
K. van de Ven, B. de Galan, M. van der Graaf, A. Shestov, P. Henry, C. Tack and A. Heerschap. "Effect of acute hypoglycemia on human cerebral glucose metabolism measured by 13C magnetic resonance spectroscopy", 2011. Abstract/PDF DOI PMID
M. Visser, N. Lammers, A. Nederveen, M. van der Graaf, A. Heerschap, M. Ackermans, H. Sauerwein, E. Stroes and M. Serlie. "Hepatic steatosis does not cause insulin resistance in people with familial hypobetalipoproteinaemia", 2011. Abstract/PDF DOI PMID
D. Vriens, L. de Geus-Oei, A. Heerschap, H. van Laarhoven and W. Oyen. "Vascular and metabolic response to bevacizumab-containing regimens in two patients with colorectal liver metastases measured by dynamic contrast-enhanced MRI and dynamic 18F-FDG-PET", 2011. Abstract/PDF DOI PMID

2010

M. van der Zande, B. Sitharaman, X. Walboomers, L. Tran, J. Ananta, A. Veltien, L. Wilson, J. Alava, A. Heerschap, A. Mikos and J. Jansen. "In Vivo Magnetic Resonance Imaging of the Distribution Pattern of Gadonanotubes Released from a Degrading Poly(Lactic-Co-Glycolic Acid) Scaffold", 2010. Abstract/PDF DOI PMID
J. Wijnen, J. van Asten, D. Klomp, T. Sjobakk, I. Gribbestad, T. Scheenen and A. Heerschap. "Short echo time 1H MRSI of the human brain at 3T with adiabatic slice-selective refocusing pulses; reproducibility and variance in a dual center setting", 2010. Abstract/PDF DOI PMID
J. Wijnen, M. van der Graaf, T. Scheenen, D. Klomp, B. de Galan, A. Idema and A. Heerschap. "In vivo 13C magnetic resonance spectroscopy of a human brain tumor after application of 13C-1-enriched glucose", 2010. Abstract/PDF DOI PMID
J. Wijnen, T. Scheenen, D. Klomp and A. Heerschap. "31P magnetic resonance spectroscopic imaging with polarisation transfer of phosphomono- and diesters at 3 T in the human brain: relation with age and spatial differences", 2010. Abstract/PDF DOI PMID
G. Gambarota, H. van Laarhoven, M. Philippens, W. Peeters, P. Rijken, A. van der Kogel, C. Punt and A. Heerschap. "Assessment of Blood Hemodynamics by USPIO-Induced R(1) Changes in MRI of Murine Colon Carcinoma", 2010. Abstract/PDF DOI PMID
M. Henneke, S. Dreha-Kulaczewski, K. Brockmann, M. van der Graaf, M. Willemsen, U. Engelke, P. Dechent, A. Heerschap, G. Helms, R. Wevers and J. Gärtner. "In vivo proton MR spectroscopy findings specific for adenylosuccinate lyase deficiency", 2010. Abstract/PDF DOI PMID
H. Kan, D. Klomp, M. Wohlgemuth, I. van Loosbroek-Wagemans, B. van Engelen, G. Padberg and A. Heerschap. "Only fat infiltrated muscles in resting lower leg of FSHD patients show disturbed energy metabolism", 2010. Abstract/PDF DOI PMID
H. van Laarhoven, W. Fiedler, I. Desar, J. van Asten, S. Marréaud, D. Lacombe, A. Govaerts, J. Bogaerts, P. Lasch, J. Timmer-Bonte, A. Lambiase, C. Bordignon, C. Punt, A. Heerschap and C. van Herpen. "Phase I clinical and magnetic resonance imaging study of the vascular agent NGR-hTNF in patients with advanced cancers (European Organization for Research and Treatment of Cancer Study 16041)", 2010. Abstract/PDF DOI PMID
C. Nabuurs, B. Huijbregts, B. Wieringa, C. Hilbers and A. Heerschap. "31P saturation transfer spectroscopy predicts differential intracellular macromolecular association of ATP and ADP in skeletal muscle", 2010. Abstract/PDF DOI PMID
M. Srinivas, E. Aarntzen, J. Bulte, W. Oyen, A. Heerschap, I. de Vries and C. Figdor. "Imaging of cellular therapies", 2010. Abstract/PDF DOI PMID
M. Srinivas, L. Cruz, F. Bonetto, A. Heerschap, C. Figdor and I. de Vries. "Customizable, multi-functional fluorocarbon nanoparticles for quantitative in vivo imaging using 19F MRI and optical imaging", 2010. Abstract/PDF DOI PMID
M. Srinivas, A. Heerschap, E. Ahrens, C. Figdor and I. de Vries. "(19)F MRI for quantitative in vivo cell tracking", 2010. Abstract/PDF DOI PMID
M. van der Graaf, C. Tack, J. de Haan, D. Klomp and A. Heerschap. "Magnetic resonance spectroscopy shows an inverse correlation between intramyocellular lipid content in human calf muscle and local glycogen synthesis rate", 2010. Abstract/PDF DOI PMID
B. Sitharaman, M. Zande, J. Ananta, X. Shi, A. Veltien, X. Walboomers, L. Wilson, A. Mikos, A. Heerschap and J. Jansen. "Magnetic resonance imaging studies on gadonanotube-reinforced biodegradable polymer nanocomposites", 2010. Abstract/PDF DOI PMID
K. van de Ven, M. van der Graaf, C. Tack, D. Klomp, A. Heerschap and B. de Galan. "Optimized [1-(13)C]glucose infusion protocol for 13C magnetic resonance spectroscopy at 3T of human brain glucose metabolism under euglycemic and hypoglycemic conditions", 2010. Abstract/PDF DOI PMID

2009

D. Klomp, A. Bitz, A. Heerschap and T. Scheenen. "Proton spectroscopic imaging of the human prostate at 7 T", 2009. Abstract/PDF DOI PMID
K. Alons, M. Naphausen, J. den Hoff, P. van der Kraan, J. Maltha, A. Veltien, A. Heerschap and P. Damme. "Induction of haemarthrosis in the TMJ of rats: validation by MR imaging (MRI) and histology", 2009. PDF DOI PMID
C. Hooijmans, C. der Zee, P. Dederen, K. Brouwer, Y. Reijmer, T. van Groen, L. Broersen, D. L?tjohann, A. Heerschap and A. Kiliaan. "DHA and cholesterol containing diets influence Alzheimer-like pathology, cognition and cerebral vasculature in APPswe/PS1dE9 mice", 2009. Abstract/PDF DOI PMID
H. Kan, T. Scheenen, M. Wohlgemuth, D. Klomp, I. van Loosbroek-Wagenmans, G. Padberg and A. Heerschap. "Quantitative MR imaging of individual muscle involvement in facioscapulohumeral muscular dystrophy", 2009. Abstract/PDF DOI PMID
H. Kan, A. Veltien, H. Arnts, C. Nabuurs, B. Luijten, A. de Haan, B. Wieringa and A. Heerschap. "Gated dynamic 31P MRS shows reduced contractile phosphocreatine breakdown in mice deficient in cytosolic creatine kinase and adenylate kinase", 2009. Abstract/PDF DOI PMID
E. Kolwijck, U. Engelke, M. van der Graaf, A. Heerschap, H. Blom, M. Hadfoune, W. Buurman, L. Massuger and R. Wevers. "N-acetyl resonances in in vivo and in vitro NMR spectroscopy of cystic ovarian tumors", 2009. Abstract/PDF DOI PMID
J. Luts, T. Laudadio, A. Idema, A. Simonetti, A. Heerschap, D. Vandermeulen, J. Suykens and S. Huffel. "Nosologic imaging of the brain: segmentation and classification using MRI and MRSI", 2009. Abstract/PDF DOI PMID
M. Philippens, G. Gambarota, A. van der Kogel and A. Heerschap. "Radiation effects in the rat spinal cord: evaluation with apparent diffusion coefficient versus T2 at serial MR imaging", 2009. Abstract/PDF DOI PMID
M. Sommers, J. van Egmond, L. Booij and A. Heerschap. "Isoflurane anesthesia is a valuable alternative for alpha-chloralose anesthesia in the forepaw stimulation model in rats", 2009. Abstract/PDF DOI PMID
D. Vriens, H. van Laarhoven, J. van Asten, P. Krabbe, E. Visser, A. Heerschap, C. Punt, L. de Geus-Oei and W. Oyen. "Chemotherapy response monitoring of colorectal liver metastases by dynamic Gd-DTPA-enhanced MRI perfusion parameters and 18F-FDG PET metabolic rate", 2009. Abstract/PDF DOI PMID

2008

M. van der Graaf, M. Julià-Sapé, F. Howe, A. Ziegler, C. Majós, A. Moreno-Torres, M. Rijpkema, D. Acosta, K. Opstad, Y. van der Meulen, C. Arús and A. Heerschap. "MRS quality assessment in a multicentre study on MRS-based classification of brain tumours", 2008. Abstract/PDF DOI PMID
J. van Asten, V. Cuijpers, C. de Hulsbergen-van Kaa, C. Soede-Huijbregts, J. Witjes, A. Verhofstad and A. Heerschap. "High resolution magic angle spinning NMR spectroscopy for metabolic assessment of cancer presence and Gleason score in human prostate needle biopsies", 2008. Abstract/PDF DOI PMID
E. Cann, M. Rijpkema, A. Heerschap, A. van der Bilt, R. Koole and P. Stoelinga. "Quantitative dynamic contrast-enhanced MRI for the assessment of mandibular invasion by squamous cell carcinoma", 2008. Abstract/PDF DOI PMID
A. Claes, G. Gambarota, B. Hamans, O. van Tellingen, P. Wesseling, C. Maass, A. Heerschap and W. Leenders. "Magnetic resonance imaging-based detection of glial brain tumors in mice after antiangiogenic treatment", 2008. Abstract/PDF DOI PMID
A. Claes, P. Wesseling, J. Jeuken, C. Maass, A. Heerschap and W. Leenders. "Antiangiogenic compounds interfere with chemotherapy of brain tumors due to vessel normalization", 2008. Abstract/PDF DOI PMID
G. Gambarota, W. Leenders, C. Maass, P. Wesseling, B. van der Kogel, O. van Tellingen and A. Heerschap. "Characterisation of tumour vasculature in mouse brain by USPIO contrast-enhanced MRI", 2008. Abstract/PDF DOI PMID
D. Klomp, J. Wijnen, T. Scheenen and A. Heerschap. "Efficient 1H to 31P polarization transfer on a clinical 3T MR system", 2008. Abstract/PDF DOI PMID
J. Luts, J. Poullet, J. Garcia-Gomez, A. Heerschap, M. Robles, J. Suykens and S. Huffel. "Effect of feature extraction for brain tumor classification based on short echo time 1H MR spectra", 2008. Abstract/PDF DOI PMID
O. Mook, A. Jonker, A. Strang, A. Veltien, G. Gambarota, W. Frederiks, A. Heerschap and C. Noorden. "Noninvasive magnetic resonance imaging of the development of individual colon cancer tumors in rat liver", 2008. Abstract/PDF DOI PMID
C. Nabuurs, D. Klomp, A. Veltien, H. Kan and A. Heerschap. "Localized sensitivity enhanced in vivo 13C MRS to detect glucose metabolism in the mouse brain", 2008. Abstract/PDF DOI PMID
W. Renema, H. Kan and A. Heerschap. "Is ATP elevated in patients with GAMT deficiency?", 2008. PDF DOI PMID
T. Scheenen, A. Heerschap and D. Klomp. "Towards 1H-MRSI of the human brain at 7T with slice-selective adiabatic refocusing pulses", 2008. Abstract/PDF DOI PMID
T. Scheenen, D. Klomp, J. Wijnen and A. Heerschap. "Short echo time 1H-MRSI of the human brain at 3T with minimal chemical shift displacement errors using adiabatic refocusing pulses", 2008. Abstract/PDF DOI PMID

2007

A. Heerschap, H. Kan, C. Nabuurs, W. Renema, D. Isbrandt and B. Wieringa. "In vivo magnetic resonance spectroscopy of transgenic mice with altered expression of guanidinoacetate methyltransferase and creatine kinase isoenzymes", 2007. Abstract PMID
D. Klomp, H. van Laarhoven, T. Scheenen, Y. Kamm and A. Heerschap. "Quantitative 19F MR spectroscopy at 3 T to detect heterogeneous capecitabine metabolism in human liver", 2007. Abstract/PDF DOI PMID
G. Gambarota, A. Veltien, D. Klomp, N. Alfen, R. Mulkern and A. Heerschap. "Magnetic resonance imaging and T2 relaxometry of human median nerve at 7 Tesla", 2007. Abstract/PDF DOI PMID
S. Heijmink, T. Scheenen, J. Fütterer, D. Klomp, R. Heesakkers, C. de Kaa, E. van Lin, A. Heerschap and J. Barentsz. "Prostate and lymph node proton magnetic resonance (MR) spectroscopic imaging with external array coils at 3 T to detect recurrent prostate cancer after radiation therapy", 2007. Abstract/PDF DOI PMID
C. Hooijmans, F. Rutters, P. Dederen, G. Gambarota, A. Veltien, T. van Groen, L. Broersen, D. Lütjohann, A. Heerschap, H. Tanila and A. Kiliaan. "Changes in cerebral blood volume and amyloid pathology in aged Alzheimer APP/PS1 mice on a docosahexaenoic acid (DHA) diet or cholesterol enriched Typical Western Diet (TWD)", 2007. Abstract/PDF DOI PMID
H. Kan, E. Meeuwissen, J. van Asten, A. Veltien, D. Isbrandt and A. Heerschap. "Creatine uptake in brain and skeletal muscle of mice lacking guanidinoacetate methyltransferase assessed by magnetic resonance spectroscopy", 2007. Abstract/PDF DOI PMID
H. van Laarhoven, D. Klomp, M. Rijpkema, Y. Kamm, D. Wagener, J. Barentsz, C. Punt and A. Heerschap. "Prediction of chemotherapeutic response of colorectal liver metastases with dynamic gadolinium-DTPA-enhanced MRI and localized 19F MRS pharmacokinetic studies of 5-fluorouracil", 2007. Abstract/PDF DOI PMID
J. Luts, A. Heerschap, J. Suykens and S. Huffel. "A combined MRI and MRSI based multiclass system for brain tumour recognition using LS-SVMs with class probabilities and feature selection", 2007. Abstract/PDF DOI PMID
W. Renema, H. Kan, B. Wieringa and A. Heerschap. "In vivo magnetic resonance spectroscopy of transgenic mouse models with altered high-energy phosphoryl transfer metabolism", 2007. Abstract/PDF DOI PMID
T. Scheenen, S. Heijmink, S. Roell, C. de Hulsbergen-Van Kaa, B. Knipscheer, J. Witjes, J. Barentsz and A. Heerschap. "Three-dimensional proton MR spectroscopy of human prostate at 3 T without endorectal coil: feasibility", 2007. Abstract/PDF DOI PMID
P. Verdijk, T. Scheenen, W. Lesterhuis, G. Gambarota, A. Veltien, P. Walczak, N. Scharenborg, J. Bulte, C. Punt, A. Heerschap, C. Figdor and I. de Vries. "Sensitivity of magnetic resonance imaging of dendritic cells for in vivo tracking of cellular cancer vaccines", 2007. Abstract/PDF DOI PMID
M. Vos, T. Laudadio, A. Simonetti, A. Heerschap and S. Huffel. "Fast nosologic imaging of the brain", 2007. Abstract/PDF DOI PMID

2006

E. Abbink, J. De Graaf, J. De Haan, A. Heerschap, A. Stalenhoef and C. Tack. "Effects of pioglitazone in familial combined hyperlipidaemia", 2006. Abstract/PDF DOI PMID
F. Arias-Mendoza, G. Payne, K. Zakian, A. Schwarz, M. Stubbs, R. Stoyanova, D. Ballon, F. Howe, J. Koutcher, M. Leach, J. Griffiths, A. Heerschap, J. Glickson, S. Nelson, J. Evelhoch, H. Charles and T. Brown. "In vivo 31P MR spectral patterns and reproducibility in cancer patients studied in a multi-institutional trial", 2006. Abstract/PDF DOI PMID
G. Gambarota, H. van Laarhoven, M. Philippens, J. Lok, A. van der Kogel, C. Punt and A. Heerschap. "Assessment of absolute blood volume in carcinoma by USPIO contrast-enhanced MRI", 2006. Abstract/PDF DOI PMID
B. Hamans, M. Barth, W. Leenders and A. Heerschap. "Contrast enhanced susceptibility weighted imaging (CE-SWI) of the mouse brain using ultrasmall superparamagnetic ironoxide particles (USPIO)", 2006. Abstract/PDF DOI PMID
E. Kemper, W. Leenders, B. Küsters, S. Lyons, T. Buckle, A. Heerschap, W. Boogerd, J. Beijnen and O. van Tellingen. "Development of luciferase tagged brain tumour models in mice for chemotherapy intervention studies", 2006. Abstract/PDF DOI PMID
H. van Laarhoven, G. Gambarota, A. Heerschap, J. Lok, I. Verhagen, A. Corti, S. Toma, C. Gallo Stampino, A. van der Kogel and C. Punt. "Effects of the tumor vasculature targeting agent NGR-TNF on the tumor microenvironment in murine lymphomas", 2006. Abstract/PDF DOI PMID
H. van Laarhoven, G. Gambarota, J. Lok, M. Lammens, Y. Kamm, T. Wagener, C. Punt, A. van der Kogel and A. Heerschap. "Carbogen breathing differentially enhances blood plasma volume and 5-fluorouracil uptake in two murine colon tumor models with a distinct vascular structure", 2006. Abstract/PDF DOI PMID
H. van Laarhoven, J. Kaanders, J. Lok, W. Peeters, P. Rijken, B. Wiering, T. Ruers, C. Punt, A. Heerschap and A. van der Kogel. "Hypoxia in relation to vasculature and proliferation in liver metastases in patients with colorectal cancer", 2006. Abstract/PDF DOI PMID
H. Kan, M. van der Graaf, D. Klomp, M. Vlak, G. Padberg and A. Heerschap. "Intake of 13C-4 creatine enables simultaneous assessment of creatine and phosphocreatine pools in human skeletal muscle by 13C MR spectroscopy", 2006. Abstract/PDF DOI PMID
D. Klomp, W. Renema, M. van der Graaf, B. de Galan, A. Kentgens and A. Heerschap. "Sensitivity-enhanced 13C MR spectroscopy of the human brain at 3 Tesla", 2006. Abstract/PDF DOI PMID
A. Tate, J. Underwood, D. Acosta, M. Julia-Sapé, C. Majós, A. Moreno-Torres, F. Howe, M. van der Graaf, V. Lefournier, M. Murphy, A. Loosemore, C. Ladroue, P. Wesseling, J. Luc Bosson, M. Cabañas, A. Simonetti, W. Gajewicz, J. Calvar, A. Capdevila, P. Wilkins, B. Bell, C. Rémy, A. Heerschap, D. Watson, J. Griffiths and C. Arús. "Development of a decision support system for diagnosis and grading of brain tumours using in vivo magnetic resonance single voxel spectra", 2006. Abstract/PDF DOI PMID

2005

H. Kan, T. Buse-Pot, R. Peco, D. Isbrandt, A. Heerschap and A. de Haan. "Lower force and impaired performance during high-intensity electrical stimulation in skeletal muscle of GAMT-deficient knockout mice", 2005. Abstract/PDF DOI PMID
H. van Laarhoven, J. Bussink, J. Lok, I. Verhagen, C. Punt, A. Heerschap, J. Kaanders and A. van der Kogel. "Modulation of hypoxia in murine liver metastases of colon carcinoma by nicotinamide and carbogen", 2005. Abstract/PDF DOI PMID
H. van Laarhoven, C. Punt, Y. Kamm and A. Heerschap. "Monitoring fluoropyrimidine metabolism in solid tumors with in vivo (19)F magnetic resonance spectroscopy", 2005. Abstract/PDF DOI PMID
M. Serlie, J. de Haan, C. Tack, H. Verberne, M. Ackermans, A. Heerschap and H. Sauerwein. "Glycogen synthesis in human gastrocnemius muscle is not representative of whole-body muscle glycogen synthesis", 2005. Abstract/PDF DOI PMID
A. Simonetti, W. Melssen, F. de Szabo Edelenyi, J. van Asten, A. Heerschap and L. Buydens. "Combination of feature-reduced MR spectroscopic and MR imaging data for improved brain tumor classification", 2005. Abstract/PDF DOI PMID
H. van Laarhoven, L. de Geus-Oei, B. Wiering, J. Lok, M. Rijpkema, J. Kaanders, P. Krabbe, T. Ruers, C. Punt, A. van der Kogel, W. Oyen and A. Heerschap. "Gadopentetate dimeglumine and FDG uptake in liver metastases of colorectal carcinoma as determined with MR imaging and PET", 2005. Abstract/PDF DOI PMID
A. Devos, A. Simonetti, M. van der Graaf, L. Lukas, J. Suykens, L. Vanhamme, L. Buydens, A. Heerschap and S. Van Huffel. "The use of multivariate MR imaging intensities versus metabolic data from MR spectroscopic imaging for brain tumour classification", 2005. Abstract/PDF DOI PMID
G. Gambarota, M. van der Graaf, D. Klomp, R. Mulkern and A. Heerschap. "Echo-time independent signal modulations using PRESS sequences: a new approach to spectral editing of strongly coupled AB spin systems", 2005. Abstract/PDF DOI PMID
T. Scheenen, G. Gambarota, E. Weiland, D. Klomp, J. Fütterer, J. Barentsz and A. Heerschap. "Optimal timing for in vivo 1H-MR spectroscopic imaging of the human prostate at 3T", 2005. Abstract/PDF DOI PMID
I. de Vries, W. Lesterhuis, J. Barentsz, P. Verdijk, J. van Krieken, O. Boerman, W. Oyen, J. Bonenkamp, J. Boezeman, G. Adema, J. Bulte, T. Scheenen, C. Punt, A. Heerschap and C. Figdor. "Magnetic resonance tracking of dendritic cells in melanoma patients for monitoring of cellular therapy", 2005. Abstract/PDF DOI PMID

2004

Y. Kamm, A. Heerschap, E. van den Bergh and D. Wagener. "19F-magnetic resonance spectroscopy in patients with liver metastases of colorectal cancer treated with 5-fluorouracil", 2004. Abstract/PDF URL PMID
R. Kok, M. de Vries, A. Heerschap and P. van den Berg. "Absence of harmful effects of magnetic resonance exposure at 1.5 T in utero during the third trimester of pregnancy: a follow-up study", 2004. Abstract/PDF DOI PMID
M. Rijpkema, J. Schuuring, P. Bernsen, H. Bernsen, J. Kaanders, A. van der Kogel and A. Heerschap. "BOLD MRI response to hypercapnic hyperoxia in patients with meningiomas: correlation with Gadolinium-DTPA uptake rate", 2004. Abstract/PDF DOI PMID
F. Arias-Mendoza, K. Zakian, A. Schwartz, F. Howe, J. Koutcher, M. Leach, J. Griffiths, A. Heerschap, J. Glickson, S. Nelson, J. Evelhoch, H. Charles, T. Brown and C. on in Cancer. "Methodological standardization for a multi-institutional in vivo trial of localized 31P MR spectroscopy in human cancer research. In vitro and normal volunteer studies", 2004. Abstract/PDF DOI PMID
H. van Laarhoven, J. Bussink, J. Lok, C. Punt, A. Heerschap and A. van Der Kogel. "Effects of nicotinamide and carbogen in different murine colon carcinomas: immunohistochemical analysis of vascular architecture and microenvironmental parameters", 2004. Abstract/PDF DOI PMID
W. Leenders, B. Küsters, K. Verrijp, C. Maass, P. Wesseling, A. Heerschap, D. Ruiter, A. Ryan and R. de Waal. "Antiangiogenic therapy of cerebral melanoma metastases results in sustained tumor progression via vessel co-option", 2004. Abstract/PDF DOI PMID
M. Philippens, G. Gambarota, J. Pikkemaat, W. Peeters, A. van der Kogel and A. Heerschap. "Characterization of late radiation effects in the rat thoracolumbar spinal cord by MR imaging using USPIO", 2004. Abstract/PDF DOI PMID
E. Hartman, J. Pikkemaat, J. Van Asten, J. Vehof, A. Heerschap, W. Oyen, P. Spauwen and J. Jansen. "Demineralized bone matrix-induced ectopic bone formation in rats: in vivo study with follow-up by magnetic resonance imaging, magnetic resonance angiography, and dual-energy X-ray absorptiometry", 2004. Abstract/PDF DOI PMID
G. Gambarota, A. Veltien, H. van Laarhoven, M. Philippens, A. Jonker, O. Mook, W. Frederiks and A. Heerschap. "Measurements of T1 and T2 relaxation times of colon cancer metastases in rat liver at 7 T", 2004. Abstract/PDF DOI PMID
A. Devos, L. Lukas, A. Simonetti, J. Suykens, L. Vanhamme, M. van der Graaf, L. Buydens, A. Heerschap and S. Van Huffel. "Does the combination of magnetic resonance imaging and spectroscopic imaging improve the classification of brain tumours?", 2004. Abstract DOI PMID
F. van Dorsten, M. van der Graaf, M. Engelbrecht, G. van Leenders, A. Verhofstad, M. Rijpkema, J. de la Rosette, J. Barentsz and A. Heerschap. "Combined quantitative dynamic contrast-enhanced MR imaging and (1)H MR spectroscopic imaging of human prostate cancer", 2004. Abstract/PDF DOI PMID
M. van der Graaf, S. Janssen, J. van Asten, A. Hermus, C. Sweep, J. Pikkemaat, G. Martens and A. Heerschap. "Metabolic profile of the hippocampus of Zucker Diabetic Fatty rats assessed by in vivo 1H magnetic resonance spectroscopy", 2004. Abstract/PDF DOI PMID
A. Heerschap, M. Sommers, H. in 't Zandt, W. Renema, A. Veltien and D. Klomp. "Nuclear magnetic resonance in laboratory animals", 2004. DOI PMID
H. Kan, W. Renema, D. Isbrandt and A. Heerschap. "Phosphorylated guanidinoacetate partly compensates for the lack of phosphocreatine in skeletal muscle of mice lacking guanidinoacetate methyltransferase", 2004. Abstract/PDF DOI PMID
D. Klomp, M. van der Graaf, M. Willemsen, Y. van der Meulen, A. Kentgens and A. Heerschap. "Transmit/receive headcoil for optimal 1H MR spectroscopy of the brain in paediatric patients at 3T", 2004. Abstract/PDF DOI PMID
A. Schmidt, B. Marescau, E. Boehm, W. Renema, R. Peco, A. Das, R. Steinfeld, S. Chan, J. Wallis, M. Davidoff, K. Ullrich, R. Waldschütz, A. Heerschap, P. De Deyn, S. Neubauer and D. Isbrandt. "Severely altered guanidino compound levels, disturbed body weight homeostasis and impaired fertility in a mouse model of guanidinoacetate N-methyltransferase (GAMT) deficiency", 2004. Abstract/PDF DOI PMID
M. Willemsen, M. Der Van Graaf, M. Der Van Knaap, A. Heerschap, P. Van Domburg, F. Gabreëls and J. Rotteveel. "MR imaging and proton MR spectroscopic studies in SjÃ¯Â¿Â½gren-Larsson syndrome: characterization of the leukoencephalopathy", 2004. Abstract/PDF PMID
H. in 't Zandt, W. Renema, F. Streijger, C. Jost, D. Klomp, F. Oerlemans, C. der Van Zee, B. Wieringa and A. Heerschap. "Cerebral creatine kinase deficiency influences metabolite levels and morphology in the mouse brain: a quantitative in vivo 1H and 31P magnetic resonance study", 2004. Abstract/PDF DOI PMID
T. Scheenen, D. Klomp, S. Röll, J. Fütterer, J. Barentsz and A. Heerschap. "Fast acquisition-weighted three-dimensional proton MR spectroscopic imaging of the human prostate", 2004. Abstract/PDF DOI PMID

2003

J. de Haan, D. Klomp, C. Tack and A. Heerschap. "Optimized detection of changes in glucose-6-phosphate levels in human skeletal muscle by 31P MR spectroscopy", 2003. Abstract/PDF DOI PMID
A. Heerschap, R. Kok and P. van den Berg. "Antenatal proton MR spectroscopy of the human brain in vivo", 2003. Abstract/PDF DOI PMID
B. Küsters, R. de Waal, P. Wesseling, K. Verrijp, C. Maass, A. Heerschap, J. Barentsz, F. Sweep, D. Ruiter and W. Leenders. "Differential effects of vascular endothelial growth factor A isoforms in a mouse brain metastasis model of human melanoma", 2003. Abstract/PDF URL PMID
Y. Kamm, G. Peters, W. Hull, C. Punt and A. Heerschap. "Correlation between 5-fluorouracil metabolism and treatment response in two variants of C26 murine colon carcinoma", 2003. Abstract/PDF DOI PMID
D. Klomp, H. Van Laarhoven, A. Kentgens and A. Heerschap. "Optimization of localized 19F magnetic resonance spectroscopy for the detection of fluorinated drugs in the human liver", 2003. Abstract/PDF DOI PMID
R. Kok, R. Steegers-Theunissen, T. Eskes, A. Heerschap and P. van den Berg. "Decreased relative brain tissue levels of inositol in fetal hydrocephalus", 2003. Abstract/PDF DOI PMID
H. van Laarhoven, D. Klomp, Y. Kamm, C. Punt and A. Heerschap. "In vivo monitoring of capecitabine metabolism in human liver by 19fluorine magnetic resonance spectroscopy at 1.5 and 3 Tesla field strength", 2003. Abstract/PDF URL PMID
H. van Laarhoven, M. Rijpkema, C. Punt, T. Ruers, J. Hendriks, J. Barentsz and A. Heerschap. "Method for quantitation of dynamic MRI contrast agent uptake in colorectal liver metastases", 2003. Abstract/PDF DOI PMID
W. Leenders, B. Küsters, J. Pikkemaat, P. Wesseling, D. Ruiter, A. Heerschap, J. Barentsz and R. de Waal. "Vascular endothelial growth factor-A determines detectability of experimental melanoma brain metastasis in GD-DTPA-enhanced MRI", 2003. Abstract/PDF DOI PMID
S. Robinson, P. Rijken, F. Howe, P. McSheehy, B. van der Sanden, A. Heerschap, M. Stubbs, A. van der Kogel and J. Griffiths. "Tumor vascular architecture and function evaluated by non-invasive susceptibility MRI methods and immunohistochemistry", 2003. Abstract/PDF DOI PMID
A. Van Cappellen Van Walsum, M. Rijpkema, A. Heerschap, B. Oeseburg, J. Nijhuis and H. Jongsma. "Cerebral (31)P magnetic resonance spectroscopy and systemic acid-base balance during hypoxia in fetal sheep", 2003. Abstract/PDF DOI PMID
W. Renema, D. Klomp, M. Philippens, A. van den Bergh, B. Wieringa and A. Heerschap. "Magnetization transfer effect on the creatine methyl resonance studied by CW off-resonance irradiation in human skeletal muscle on a clinical MR system", 2003. Abstract/PDF DOI PMID
W. Renema, A. Schmidt, J. van Asten, F. Oerlemans, K. Ullrich, B. Wieringa, D. Isbrandt and A. Heerschap. "MR spectroscopy of muscle and brain in guanidinoacetate methyltransferase (GAMT)-deficient mice: validation of an animal model to study creatine deficiency", 2003. Abstract/PDF DOI PMID
M. Rijpkema, J. Schuuring, Y. van der Meulen, M. van der Graaf, H. Bernsen, R. Boerman, A. van der Kogel and A. Heerschap. "Characterization of oligodendrogliomas using short echo time 1H MR spectroscopic imaging", 2003. Abstract/PDF DOI PMID
A. Simonetti, W. Melssen, M. van der Graaf, G. Postma, A. Heerschap and L. Buydens. "A chemometric approach for brain tumor classification using magnetic resonance imaging and spectroscopy", 2003. Abstract PMID
H. Witjes, M. Rijpkema, M. van der Graaf, W. Melssen, A. Heerschap and L. Buydens. "Multispectral magnetic resonance image analysis using principal component and linear discriminant analysis", 2003. Abstract/PDF DOI PMID
H. in 't Zandt, A. de Groof, W. Renema, F. Oerlemans, D. Klomp, B. Wieringa and A. Heerschap. "Presence of (phospho)creatine in developing and adult skeletal muscle of mice without mitochondrial and cytosolic muscle creatine kinase isoforms", 2003. Abstract/PDF DOI PMID

2002

E. Hartman, J. Pikkemaat, J. Vehof, A. Heerschap, J. Jansen and P. Spauwen. "In vivo magnetic resonance imaging explorative study of ectopic bone formation in the rat", 2002. Abstract/PDF DOI PMID
C. Houtman, A. Heerschap, M. Zwarts and D. Stegeman. "An additional phase in PCr use during sustained isometric exercise at 30% MVC in the tibialis anterior muscle", 2002. Abstract/PDF DOI PMID
C. Jost, C. Der Van Zee, H. In 't Zandt, F. Oerlemans, M. Verheij, F. Streijger, J. Fransen, A. Heerschap, A. Cools and B. Wieringa. "Creatine kinase B-driven energy transfer in the brain is important for habituation and spatial learning behaviour, mossy fibre field size and determination of seizure susceptibility", 2002. Abstract/PDF DOI PMID
R. Kok, P. van den Berg, A. van den Bergh, R. Nijland and A. Heerschap. "Maturation of the human fetal brain as observed by 1H MR spectroscopy", 2002. Abstract/PDF DOI PMID
R. Kok, P. van den Berg, A. van den Bergh, R. Nijland and A. Heerschap. "MR spectroscopy in the human fetus", 2002. PDF DOI PMID
R. Legtenberg, R. Houston, A. Heerschap, B. Oeseburg and P. Smits. "Glibenclamide attenuates ischemia-induced acidosis and loss of cardiac function in rats", 2002. Abstract/PDF DOI PMID
M. Rijpkema, J. Kaanders, F. Joosten, A. van der Kogel and A. Heerschap. "Effects of breathing a hyperoxic hypercapnic gas mixture on blood oxygenation and vascularity of head-and-neck tumors as measured by magnetic resonance imaging", 2002. Abstract/PDF DOI PMID
J. Schuuring, M. Rijpkema, H. Bernsen, P. Bernsen, R. van der Maazen, J. Kaanders, A. van der Kogel and A. Heerschap. "Effect of breathing a hyperoxic hypercapnic gas mixture on the oxygenation of meningiomas; preliminary results", 2002. Abstract/PDF DOI PMID
A. Shukla-Dave, H. Poptani, L. Loevner, A. Mancuso, H. Serrai, D. Rosenthal, A. Kilger, D. Nelson, K. Zakian, F. Arias-Mendoza, M. Rijpkema, J. Koutcher, T. Brown, A. Heerschap and J. Glickson. "Prediction of treatment response of head and neck cancers with P-31 MR spectroscopy from pretreatment relative phosphomonoester levels", 2002. Abstract/PDF DOI PMID
M. Verhoye, B. van der Sanden, P. Rijken, H. Peters, A. der Van Kogel, G. Pée, G. Vanhoutte, A. Heerschap and A. der Van Linden. "Assessment of the neovascular permeability in glioma xenografts by dynamic T(1) MRI with Gadomer-17", 2002. Abstract/PDF DOI PMID
A. Simonetti, W. Melssen, M. van der Graaf, A. Heerschap and L. Buydens. "Automated correction of unwanted phase jumps in reference signals which corrupt MRSI spectra after eddy current correction", 2002. Abstract/PDF PMID

2001

C. Houtman, A. Heerschap, M. Zwarts and D. Stegeman. "pH heterogeneity in tibial anterior muscle during isometric activity studied by (31)P-NMR spectroscopy", 2001. Abstract/PDF URL PMID
D. Klomp, D. Collins, H. van den Boogert, A. Schwarz, M. Rijpkema, T. Prock, G. Payne, M. Leach and A. Heerschap. "Radio-frequency probe for 1H decoupled 31P MRS of the head and neck region", 2001. Abstract/PDF DOI PMID
R. Kok, A. van den Bergh, A. Heerschap, R. Nijland and P. van den Berg. "Metabolic information from the human fetal brain obtained with proton magnetic resonance spectroscopy", 2001. Abstract/PDF DOI PMID
H. in 't Zandt, M. van Der Graaf and A. Heerschap. "Common processing of in vivo MR spectra", 2001. Abstract/PDF PMID

2000

H. in 't Zandt, D. Klomp, F. Oerlemans, B. Wieringa, C. Hilbers and A. Heerschap. "Proton MR spectroscopy of wild-type and creatine kinase deficient mouse skeletal muscle: dipole-dipole coupling effects and post-mortem changes", 2000. Abstract/PDF DOI PMID
E. Janssen, P. Dzeja, F. Oerlemans, A. Simonetti, A. Heerschap, A. de Haan, P. Rush, R. Terjung, B. Wieringa and A. Terzic. "Adenylate kinase 1 gene deletion disrupts muscle energetic economy despite metabolic rearrangement", 2000. Abstract/PDF DOI PMID
Y. Kamm, A. Heerschap and D. Wagener. "Effect of carbogen breathing on the pharmacodynamics of 5-fluorouracil in a murine colon carcinoma", 2000. Abstract/PDF DOI PMID
B. van der Sanden, T. Rozijn, P. Rijken, H. Peters, A. Heerschap, A. van der Kogel and W. Bovée. "Noninvasive assessment of the functional neovasculature in 9L-glioma growing in rat brain by dynamic 1H magnetic resonance imaging of gadolinium uptake", 2000. Abstract/PDF DOI PMID
A. Schwarz, M. Rijpkema, D. Collins, G. Payne, T. Prock, A. Woodward, A. Heerschap and M. Leach. "SAR and tissue heating with a clinical (31)P MRS protocol using surface coils, adiabatic pulses, and proton-decoupling", 2000. Abstract/PDF DOI PMID
A. Den Van Bergh, C. Tack, H. Den Van Boogert, G. Vervoort, P. Smits and A. Heerschap. "Assessment of human muscle glycogen synthesis and total glucose content by in vivo 13C MRS", 2000. Abstract/PDF DOI PMID
M. Willemsen, J. Rotteveel, P. Steijlen, A. Heerschap and E. Mayatepek. "5-Lipoxygenase inhibition: a new treatment strategy for Sj"ogren-Larsson syndrome", 2000. Abstract/PDF DOI PMID
M. Engelbrecht, J. Barentsz, G. Jager, M. van der Graaf, A. Heerschap, J. Sedelaar, R. Aarnink and J. de la Rosette. "Prostate cancer staging using imaging", 2000. PDF PMID
M. van der Graaf, R. Schipper, G. Oosterhof, J. Schalken, A. Verhofstad and A. Heerschap. "Proton MR spectroscopy of prostatic tissue focused on the detection of spermine, a possible biomarker of malignant behavior in prostate cancer", 2000. Abstract PMID
H. Witjes, W. Melssen, H. in 't Zandt, M. van der Graaf, A. Heerschap and L. Buydens. "Automatic correction for phase shifts, frequency shifts, and lineshape distortions across a series of single resonance lines in large spectral data sets", 2000. Abstract/PDF DOI PMID

1999

A. van Cappellen, A. Heerschap, J. Nijhuis, B. Oeseburg and H. Jongsma. "Hypoxia, the subsequent systemic metabolic acidosis, and their relationship with cerebral metabolite concentrations: An in vivo study in fetal lambs with proton magnetic resonance spectroscopy", 1999. Abstract/PDF DOI PMID
P. van Domburg, M. Willemsen, J. Rotteveel, J. de Jong, H. Thijssen, A. Heerschap, J. Cruysberg, R. Wanders, F. Gabreëls and P. Steijlen. "Sj"ogren-Larsson syndrome: clinical and MRI/MRS findings in FALDH-deficient patients", 1999. Abstract/PDF DOI PMID
M. van der Graaf, H. van den Boogert, G. Jager, J. Barentsz and A. Heerschap. "Human prostate: multisection proton MR spectroscopic imaging with a single spin-echo sequence--preliminary experience", 1999. Abstract/PDF DOI PMID
A. Heerschap, C. Houtman, H. in 't Zandt, A. van den Bergh and B. Wieringa. "Introduction to in vivo 31P magnetic resonance spectroscopy of (human) skeletal muscle", 1999. Abstract/PDF DOI PMID
H. in 't Zandt, F. Oerlemans, B. Wieringa and A. Heerschap. "Effects of ischemia on skeletal muscle energy metabolism in mice lacking creatine kinase monitored by in vivo 31P nuclear magnetic resonance spectroscopy", 1999. Abstract/PDF DOI PMID
S. Moolenaar, J. Poggi-Bach, U. Engelke, J. Corstiaensen, A. Heerschap, J. de Jong, B. Binzak, J. Vockley and R. Wevers. "Defect in dimethylglycine dehydrogenase, a new inborn error of metabolism: NMR spectroscopy study", 1999. Abstract/PDF URL PMID
T. Rozijn, B. van der Sanden, A. Heerschap, J. Creyghton and W. Boveé. "Determination of in vivo rat muscle Gd-DTPA relaxivity at 6.3 T", 1999. Abstract/PDF DOI PMID
M. Rubio-Gozalbo, A. Heerschap, J. Trijbels, L. De Meirleir, H. Thijssen and J. Smeitink. "Proton MR spectroscopy in a child with pyruvate dehydrogenase complex deficiency", 1999. Abstract/PDF DOI PMID
B. van der Sanden, A. Heerschap, L. Hoofd, A. Simonetti, K. Nicolay, A. van der Toorn, W. Colier and A. van der Kogel. "Effect of carbogen breathing on the physiological profile of human glioma xenografts", 1999. Abstract/PDF DOI PMID
B. van der Sanden, A. Heerschap, A. Simonetti, P. Rijken, H. Peters, G. Stüben and A. van der Kogel. "Characterization and validation of noninvasive oxygen tension measurements in human glioma xenografts by 19F-MR relaxometry", 1999. Abstract/PDF DOI PMID
B. van der Sanden, H. in't Zandt, L. Hoofd, R. de Graaf, K. Nicolay, P. Rijken, A. van der Kogel and A. Heerschap. "Global HDO uptake in human glioma xenografts is related to the perfused capillary distribution", 1999. Abstract/PDF DOI PMID

1998

A. van den Bergh, H. van den Boogert and A. Heerschap. "Heteronuclear cross polarization for enhanced sensitivity of in vivo 13C MR spectroscopy on a clinical 1.5 T MR system", 1998. Abstract/PDF DOI PMID
A. van den Bergh, H. van den Boogert and A. Heerschap. "Calibration of the 1H decoupling field strength and experimental evaluation of the specific RF absorption rate in 1H-decoupled human 13C-MRS", 1998. Abstract/PDF DOI PMID
A. van van Cappellen Walsum, A. Heerschap, J. Nijhuis, B. Oeseburg and H. Jongsma. "Proton magnetic resonance spectroscopy of fetal lamb brain during hypoxia", 1998. Abstract/PDF DOI PMID
H. in 't Zandt, B. Wieringa and A. Heerschap. "Creatine kinase knockout mice--what is the phenotype: skeletal muscle", 1998. PDF URL PMID
L. Massuger, P. van Vierzen, U. Engelke, A. Heerschap and R. Wevers. "1H-magnetic resonance spectroscopy: a new technique to discriminate benign from malignant ovarian tumors", 1998. Abstract/PDF DOI PMID
T. Rozijn, B. van der Sanden, A. Heerschap, J. Creyghton and W. Bovée. "Influence of the pharmacokinetic model on the quantification of the Gd-DTPA uptake rate in brain tumours using direct T1 measurements", 1998. Abstract/PDF DOI PMID
K. Steeghs, F. Oerlemans, A. de Haan, A. Heerschap, L. Verdoodt, M. de Bie, W. Ruitenbeek, A. Benders, C. Jost, J. van Deursen, P. Tullson, R. Terjung, P. Jap, W. Jacob, D. Pette and B. Wieringa. "Cytoarchitectural and metabolic adaptations in muscles with mitochondrial and cytosolic creatine kinase deficiencies", 1998. Abstract/PDF DOI PMID

1997

W. Bovée, T. Rozijn, B. Der Van Sanden and A. Heerschap. "NMR perfusion and metabolic imaging and some examples on brain tumours", 1997. Abstract URL PMID
M. van der Graaf, G. Jager and A. Heerschap. "Removal of the outer lines of the citrate multiplet in proton magnetic resonance spectra of the prostatic gland by accurate timing of a point-resolved spectroscopy pulse sequence", 1997. Abstract/PDF DOI PMID
B. van der Sanden, P. Rijken, A. Heerschap, H. Bernsen and A. van der Kogel. "In vivo (31)P magnetic resonance spectroscopy and morphometric analysis of the perfused vascular architecture of human glioma xenografts in nude mice", 1997. Abstract/PDF DOI PMID
K. Steeghs, A. Benders, F. Oerlemans, A. de Haan, A. Heerschap, W. Ruitenbeek, C. Jost, J. van Deursen, B. Perryman, D. Pette, M. Brückwilder, J. Koudijs, P. Jap, J. Veerkamp and B. Wieringa. "Altered Ca2+ responses in muscles with combined mitochondrial and cytosolic creatine kinase deficiencies", 1997. Abstract/PDF DOI PMID
K. Steeghs, A. Heerschap, A. de Haan, W. Ruitenbeek, F. Oerlemans, J. van Deursen, B. Perryman, D. Pette, M. Brückwilder, J. Koudijs, P. Jap and B. Wieringa. "Use of gene targeting for compromising energy homeostasis in neuro-muscular tissues: the role of sarcomeric mitochondrial creatine kinase", 1997. Abstract/PDF DOI PMID
A. Heerschap, G. Jager, M. van der Graaf, J. Barentsz and S. Ruijs. "Proton MR spectroscopy of the normal human prostate with an endorectal coil and a double spin-echo pulse sequence", 1997. Abstract PMID
A. Heerschap, G. Jager, M. van der Graaf, J. Barentsz, J. de la Rosette, G. Oosterhof, E. Ruijter and S. Ruijs. "In vivo proton MR spectroscopy reveals altered metabolite content in malignant prostate tissue", 1997. Abstract/PDF URL PMID

1996

Y. Kamm, A. Heerschap, G. Rosenbusch, I. Rietjens, J. Vervoort and D. Wagener. "5-Fluorouracil metabolite patterns in viable and necrotic tumor areas of murine colon carcinoma determined by 19F NMR spectroscopy", 1996. Abstract/PDF DOI PMID
W. Negendank, R. Sauter, T. Brown, J. Evelhoch, A. Falini, E. Gotsis, A. Heerschap, K. Kamada, B. Lee, M. Mengeot, E. Moser, K. Padavic-Shaller, J. Sanders, T. Spraggins, A. Stillman, B. Terwey, T. Vogl, K. Wicklow and R. Zimmerman. "Proton magnetic resonance spectroscopy in patients with glial tumors: a multicenter study", 1996. Abstract/PDF DOI PMID
A. Den Van Bergh, S. Houtman, A. Heerschap, N. Rehrer, H. Den Van Boogert, B. Oeseburg and M. Hopman. "Muscle glycogen recovery after exercise during glucose and fructose intake monitored by 13C-NMR", 1996. Abstract/PDF URL PMID
M. van der Graaf and A. Heerschap. "Effect of Cation Binding on the Proton Chemical Shifts and the Spin-Spin Coupling Constant of Citrate", 1996. PMID

1995

N. Abeling, A. van Gennip, H. Bakker, A. Heerschap, U. Engelke and R. Wevers. "Diagnosis of a new case of trimethylaminuria using direct proton NMR spectroscopy of urine", 1995. PDF URL PMID
E. Cornel, G. Smits, F. Debruyne, A. Heerschap, J. Schalken and G. Oosterhof. "The effects of successive high-energy shock-wave tumor administration on tumor blood flow", 1995. Abstract/PDF DOI PMID
E. Cornel, G. Smits, J. de Ruijter, G. Oosterhof, A. Heerschap, F. Debruyne and J. Schalken. "In vitro proton magnetic resonance spectroscopy of four human prostate cancer cell lines", 1995. Abstract/PDF DOI PMID
B. Holshouser, M. Komu, H. Möller, J. Zijlmans, H. Kolem, D. Hinshaw Jr, P. Sonninen, P. Vermathen, A. Heerschap and H. Masur. "Localized proton NMR spectroscopy in the striatum of patients with idiopathic Parkinson's disease: a multicenter pilot study", 1995. Abstract/PDF DOI PMID
R. Wevers, U. Engelke, U. Wendel, J. de Jong, F. Gabreëls and A. Heerschap. "Standardized method for high-resolution 1H-NMR of cerebrospinal fluid", 1995. Abstract/PDF URL PMID

1994

E. Cornel, A. Heerschap, G. Smits, G. Oosterhof, F. Debruyne and J. Schalken. "Magnetic resonance spectroscopy detects metabolic differences between seven Dunning rat prostate tumor sublines with different biological behavior", 1994. Abstract DOI PMID
J. van Deursen, P. Jap, A. Heerschap, H. ter Laak, W. Ruitenbeek and B. Wieringa. "Effects of the creatine analogue beta-guanidinopropionic acid on skeletal muscles of mice deficient in muscle creatine kinase", 1994. Abstract PMID
J. van Deursen, W. Ruitenbeek, A. Heerschap, P. Jap, H. ter Laak and B. Wieringa. "Creatine kinase (CK) in skeletal muscle energy metabolism: a study of mouse mutants with graded reduction in muscle CK expression", 1994. Abstract/PDF URL PMID
A. Heerschap and P. van den Berg. "Proton magnetic resonance spectroscopy of human fetal brain", 1994. Abstract DOI PMID
V. Kamm, I. Rietjens, J. Vervoort, A. Heerschap, G. Rosenbusch, H. Hofs and D. Wagener. "Effect of modulators on 5-fluorouracil metabolite patterns in murine colon carcinoma determined by in vitro 19F nuclear magnetic resonance spectroscopy", 1994. Abstract/PDF URL PMID
G. Smits, E. Cornel, E. van de Boogert, G. Oosterhof, F. Debruyne, J. Schalken and A. Heerschap. "Effects of high energy shock waves on tumor blood flow and metabolism: 31P/1H/2H nuclear magnetic resonance study", 1994. Abstract DOI PMID
R. Wevers, U. Engelke and A. Heerschap. "High-resolution 1H-NMR spectroscopy of blood plasma for metabolic studies", 1994. Abstract/PDF URL PMID
J. Zijlmans, A. de Koster, M. van 't Hof, H. Thijssen, M. Horstink and A. Heerschap. "Proton magnetic resonance spectroscopy in suspected vascular ischemic parkinsonism", 1994. Abstract/PDF DOI PMID

1993

E. Cornel, G. Smits, G. Oosterhof, H. Karthaus, F. Deburyne, J. Schalken and A. Heerschap. "Characterization of human prostate cancer, benign prostatic hyperplasia and normal prostate by in vitro 1H and 31P magnetic resonance spectroscopy", 1993. Abstract PMID
J. van Deursen, A. Heerschap, F. Oerlemans, W. Ruitenbeek, P. Jap, H. ter Laak and B. Wieringa. "Skeletal muscles of mice deficient in muscle creatine kinase lack burst activity", 1993. Abstract/PDF DOI PMID
A. Heerschap, J. den Hollander, H. Reynen and R. Goris. "Metabolic changes in reflex sympathetic dystrophy: a 31P NMR spectroscopy study", 1993. Abstract DOI PMID
G. Smits, P. Jap, A. Heerschap, G. Oosterhof, F. Debruyne and J. Schalken. "Biological effects of high energy shock waves in mouse skeletal muscle: correlation between 31P magnetic resonance spectroscopic and microscopic alterations", 1993. Abstract PMID

1992

H. Bernsen, A. Heerschap, A. van der Kogel, J. van Vaals, M. Prick, E. Poels, J. Meyer and J. Grotenhuis. "Image-guided 1H NMR spectroscopical and histological characterization of a human brain tumor model in the nude rat; a new approach to monitor changes in tumor metabolism", 1992. Abstract/PDF URL PMID
H. Bernsen, W. Verhagen, M. de Bijl and A. Heerschap. "Magnetic resonance studies on brain dysfunction induced by organic solvents", 1992. Abstract PMID
A. Heerschap. "Current status of human in vivo NMR spectroscopy", 1992. Abstract/PDF DOI PMID

1991

G. Smits, A. Heerschap, G. Oosterhof, J. Ruys, C. Hilbers, F. Debruyne and J. Schalken. "Early metabolic response to high energy shock waves in a human tumor kidney xenograft monitored by 31P magnetic resonance spectroscopy", 1991. Abstract/PDF DOI PMID
J. van Vaals, A. Bergman, H. van den Boogert, A. Heerschap, A. van der Kogel, A. Ruifrok and H. Bernsen. "Non-invasive in vivo localized 1H spectroscopy of human astrocytoma implanted in rat brain: regional differences followed in time", 1991. Abstract DOI PMID

1989

A. Heerschap, P. Luyten, J. van der Heyden, L. Oosterwaal and J. den Hollander. "Broadband proton decoupled natural abundance 13C NMR spectroscopy of humans at 1.5 T", 1989. Abstract DOI PMID
P. Luyten, G. Bruntink, F. Sloff, J. Vermeulen, J. van der Heijden, J. den Hollander and A. Heerschap. "Broadband proton decoupling in human 31P NMR spectroscopy", 1989. Abstract DOI PMID

1988

A. Heerschap, A. Bergman, J. van Vaals, P. Wirtz, H. Loermans and J. Veerkamp. "Alterations in relative phosphocreatine concentrations in preclinical mouse muscular dystrophy revealed by in vivo NMR", 1988. Abstract DOI PMID
A. Heerschap, J. van Vaals, A. Bergman, J. den Boef, P. van Gerwen and E. Gravenmade. "In vivo 31P NMR studies of rat salivary glands at 6.3 tesla", 1988. Abstract DOI PMID