Neuromuscular disorders are slowly progressive diseases, making their progression hard to monitor. As potential treatments enter the clinical research phase, there is a growing need for sensitive, non-invasive biomarkers. Currently, preclinical structural and functional muscle imaging is underdeveloped. My research focuses on addressing this knowledge gap by combining magnetic resonance imaging, multispectral optoacoustic tomography, and ultrasound into a multi-modal imaging toolkit to assess muscle contractile function and muscle quality in mice. The multi-modal approach will allow us to capture disease activity in great detail, ultimately enhancing our capabilities to predict disease progression in neuromuscular disorders.