People of Biomedial MR

Siem Herings

My research focuses on distinguishing true tumor recurrence from treatment-related changes—such as pseudoprogression and radionecrosis—in patients with high-grade primary brain tumors. I investigate the potential of advanced magnetic resonance imaging (MRI) methods to non-invasively make this differentiation. My focus is on perfusion imaging, diffusion imaging and phosphorus-31 MR spectroscopy (³¹P MRS). These modalities can reveal subtle differences in tissue structure, blood flow, and metabolism. By providing a non-invasive way to reliably differentiate these entities, this work aims to reduce patient uncertainty, potentially enlarge the time window for additional treatments and help clinicians make better-informed treatment decisions.