Novel MR sequences for fast and robust metabolic imaging

Magnetic resonance spectroscopy (MRS) and spectroscopic imaging (MRSI) enable non-invasive assessment of metabolic processes, but their clinical use is limited by low signal strength, long acquisition times, and technical challenges—especially at high magnetic field strengths.

This thesis presents innovative MR methods to improve metabolic imaging, including faster acquisition techniques, improved localization, and reduced artifacts. Advanced sequences such as GOIA-sLASER enabled high-quality, whole-prostate metabolic imaging within clinically feasible times, with improved detection of key metabolites like choline and citrate.

These developments enhance the robustness and practicality of MRSI, supporting its future integration into clinical workflows for better diagnosis and characterization of diseases such as prostate cancer.